Cic edizioni internazionali
Shortness of Breath

MicroRNA networks during pneumonia and acute lung injury

Review, 73 - 83
doi: 10.11138/sob/2016.5.2.073
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Abstract
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MicroRNAs (miRNAs) are a group of ubiquitous and highly conserved small noncoding RNA molecules which affect gene expression by acting on mRNA at a post-transcriptional level. Their role is being increasingly elucidated as they have shown to act as fine regulators of immune response and inflammatory pathways. MiRNAs also gained great interest from a clinical standpoint, as they could serve as both tissue-specific, early circulating biomarkers of disease and outcome predictors. Furthermore, they could represent a novel therapeutic strategy given that targeted administration or inhibition of miRNAs may result in a highly specific and effective treatment.
However, poor knowledge exists about the role of miRNAs and their potential therapeutic use in respiratory infections and acute lung injury. In the present review we will discuss the current evidence regarding the application of miRNAs and their related technologies to these conditions.
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